The participants were randomized to receive either two placebos or two capsules of a multi-spore formulation, “MegaSporeBiotic,” each day for 30 days. The participants whose endotoxin level increased five-fold or greater five hours after eating the meal were considered “responders” who may have abnormalities in gut health that facilitated above average levels of endotoxin migration from the intestine. Twenty-five otherwise healthy subjects were identified as having dietary endotoxemia by measuring the endotoxin concentration in their blood following a high-fat, high-calorie meal. McFarlin’s first study was published in the “World Journal of Gastrointestinal Pathophysiology” in 2017. Dietary endotoxemia has been linked to chronic conditions such as appetite disorders, chronic constipation, auto-immune disorders, cognitive decline, mood disorders, depression, type 2 diabetes, chronic pain and cardiovascular disease. Gaps can develop in the lining that allow bacterial endotoxins to escape into the bloodstream resulting in dietary endotoxemia.Īccording to McFarlin, one-third of people living in Western society may be affected by dietary endotoxemia, an elevated level of endotoxins in the blood after eating a high-fat meal. A healthy intestinal lining forms a tight barrier that controls what gets absorbed from the intestine into the bloodstream.Ī “leaky gut” is the result of an unhealthy intestinal lining caused by the lack of beneficial bacteria. In a healthy intestine, colonies of beneficial bacteria assist in maintaining the mucous lining in the intestine and also help protect the lining against toxins, allergens and pathogens. These spore-forming or ground-based probiotic strains are more effective because the endospores that encapsulate the strains are highly resistant to stomach acid, potentially resulting in the delivery of more viable probiotics to the small intestine. McFarlin’s research focuses on subjects with health issues that may be helped by probiotics specifically spore-based probiotics. Plus, unless you have excessive endotoxins moving from your gut into your body or you have a compromised gut biome (the trillions of beneficial bacteria that populate a healthy gut), probiotics offer limited to no benefit.” “Most traditional probiotics are destroyed by our stomach acid and don’t make it to the intestine to do any good. “The current efforts to use over-the-counter probiotics, typically Lactobacillus and Bifidobacterium, to improve gut health don’t give us consistent results,” McFarlin said. Over the counter probiotic products are found in most drug and grocery stores promising to restore and promote gut health, but Brian McFarlin, a professor in the University of North Texas Departments of Kinesiology, Health Promotion and Recreation and, says consumers might want to do some research before paying for a product that may do little or nothing to improve their health.
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